Physiologic and Immunologic Hurdles to Xenotransplantation
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چکیده
منابع مشابه
Physiologic and immunologic hurdles to xenotransplantation.
The major problem in the field of renal transplantation is currently the shortage of available kidneys. However, the use of animals as a source of kidneys, i.e., xenotransplantation, is increasingly being viewed as a potential solution to this problem. One preeminent hurdle to xenotransplantation is the immune response of the recipient against the graft; other hurdles include the physiologic li...
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Sachs. In Press. Xenotransplantation from pig to cynomolgus monkey: The potential for overcoming xenograft rejection through induction of chimerism. Transplant. Proc. Thomas, J. M., M. Alqaisi. P. Cunningham. M. Carver, L. Rebellato, U. Gross, T. Patselas, D. Araneda, and F. Thomas. 1992. The development of a post-transplant TLI treatment strategy that promotes organ allograft acceptance withou...
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Binding of natural anti-pig antibodies in humans and nonhuman primates to carbohydrate antigens expressed on the transplanted pig organ, the most important of which is galactose-α1,3-galactose (Gal), activate the complement cascade, which results in destruction of the graft within minutes or hours, known as hyperacute rejection. Even if antibody is removed from the recipient's blood by plasmaph...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2001
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v121182